{"entity":{"id":"nct07381309","kind":"trial","name":"Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM","aka":["VVSHIP"],"tldr":"A phase 2 trial of fOLFIRI (5-FU, leucovorin, irinotecan) in colorectal cancer, run by Jun Huang, not yet recruiting.","summary":"Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM is a phase 2, randomised interventional study registered as NCT07381309 by Jun Huang, with a registry enrolment figure of 114 participants, started 2026-06-01 and due to reach its primary completion in 2028-02-01. Interventions recorded: SBRT; PD-1 Antibody; H101; Target Therapy; FOLFIRI; Chemotherapy. Conditions listed: CRC; Liver Metastasis Colon Cancer. Primary outcome: ORR. Colorectal eligibility wording from the registry: \"Patients with pMMR/MSS colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07381309","url":"https://clinicaltrials.gov/study/NCT07381309"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","sbrt","topoisomerase-inhibitors"],"targets":[],"drugs":["folfiri"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07381309","phase":"2","setting":"Oncolytic Virus (H101) Peritumoral Injection Combined With SBRT, Chemotherapy, Targeted Therapy, and Immunotherapy for Unresectable MSS/pMMR Colorectal Cancer Liver Metastases (CRLM)","sponsor":"Jun Huang","enrolled":114,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07381309/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"drug":[{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}