{"entity":{"id":"nct07384377","kind":"trial","name":"JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Iri","aka":[],"tldr":"A phase 3 trial of JSKN003 in colorectal cancer, run by Shanghai JMT-Bio Inc., not yet recruiting.","summary":"JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Irinotecan is a phase 3, randomised interventional study registered as NCT07384377 by Shanghai JMT-Bio Inc., with a registry enrolment figure of 123 participants, started 2026-02-06 and due to reach its primary completion in 2027-11-30. Interventions recorded: JSKN003; Physician choiced treatment, include: TAS-102, Regorafenib, Fruquintinib.. Conditions listed: HER2-positive Colorectal Cancer. Primary outcome: Progressive Free Survive (PFS) assessed by Independent Review Committee. Colorectal eligibility wording from the registry: \"* Unresectable locally advanced or distant metastatic BRAFV600E wild-type colorectal cancer diagnosed histologically or cytologically\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07384377","url":"https://clinicaltrials.gov/study/NCT07384377"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","her2-amplified-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["jskn003"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07384377","phase":"3","setting":"A Phase III Trial to Evaluate the Efficacy and Safety of JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Irinotecan","sponsor":"Shanghai JMT-Bio Inc.","enrolled":123,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07384377/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"her2-amplified-colorectal","kind":"cancer","name":"HER2-amplified colorectal cancer","route":"/cancers/her2-amplified-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"jskn003","kind":"drug","name":"JSKN003","route":"/drugs/jskn003/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}