{"entity":{"id":"nct07435584","kind":"trial","name":"Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE)","aka":["EVER-RECODE"],"tldr":"A phase 1/2 trial in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, not yet recruiting.","summary":"Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE) is a phase 1/2, interventional study registered as NCT07435584 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 38 participants, started 2026-03-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: Everolimus (Afinitor) tablets. Conditions listed: Colorectal Cancer. Primary outcome: Incidence of Dose-Limiting Toxicities (DLTs); Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"Histologically confirmed metastatic colorectal cancer with documented disease progression after prior standard systemic antitumor therapies, including but not limited to oxaliplatin, fluoropyrimidine, and irinotecan\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07435584","url":"https://clinicaltrials.gov/study/NCT07435584"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07435584","phase":"1/2","setting":"Everolimus in Refractory Metastatic Colorectal Cancer With CDK12 Deficiency: A Prospective Multicenter Phase Ib/II Study (EVER-RECODE)","sponsor":"Second Affiliated Hospital, Zhejiang University, School of Medicine","enrolled":38,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07435584/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}