{"entity":{"id":"nct07438106","kind":"trial","name":"A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer","aka":[],"tldr":"A phase 2 trial in pancreatic cancer, run by The First Affiliated Hospital with Nanjing Medical University, now recruiting.","summary":"A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer is a phase 2, interventional study registered as NCT07438106 by The First Affiliated Hospital with Nanjing Medical University, with a registry enrolment figure of 30 participants, started 2026-01-28 and due to reach its primary completion in 2027-10. Interventions recorded: HRS-4642 Injection. Conditions listed: Locally Advanced Pancreatic Cancer With KRAS G12D Mutation. Primary outcome: To evaluate the efficacy of HRS-4642 combined with AG (nab-paclitaxel and gemcitabine) as conversion therapy in patients with locally advanced pancreatic cancer, as measured by the Objective Response Rate (ORR).. Pancreatic eligibility wording from the registry: \"Histologically or cytologically confirmed pancreatic ductal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07438106","url":"https://clinicaltrials.gov/study/NCT07438106"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07438106","phase":"2","setting":"A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer","sponsor":"The First Affiliated Hospital with Nanjing Medical University","enrolled":30,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07438106/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}