{"entity":{"id":"nct07448142","kind":"trial","name":"Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 2 trial of pucotenlimab in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07448142 by Sun Yat-sen University, with a registry enrolment figure of 50 participants, started 2026-03-15 and due to reach its primary completion in 2027-09-01. Interventions recorded: Low-dose radiotherapy; Pucotenlimab; CAPEOX/XELOX. Conditions listed: Colorectal Cancer (CRC). Primary outcome: Complete Response Rate (CR). Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07448142","url":"https://clinicaltrials.gov/study/NCT07448142"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":["pucotenlimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07448142","phase":"2","setting":"A Randomized, Two-Arm, Open-Label Phase II Trial of Low-Dose Radiotherapy Sensitization Combined With Pucotenlimab and CAPEOX as Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Adenocarcinoma","sponsor":"Sun Yat-sen University","enrolled":50,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07448142/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"pucotenlimab","kind":"drug","name":"Pucotenlimab","route":"/drugs/pucotenlimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}