{"entity":{"id":"nct07458113","kind":"trial","name":"Sac-TMT for Active TNBC Brain Metastases","aka":["BERLIN"],"tldr":"A phase 2 trial of sacituzumab tirumotecan in triple-negative breast cancer, run by Yale University, not yet recruiting.","summary":"Sac-TMT for Active TNBC Brain Metastases is a phase 2, interventional study registered as NCT07458113 by Yale University, with a registry enrolment figure of 20 participants, started 2026-08 and due to reach its primary completion in 2028-08. Interventions recorded: Sacituzumab tirumotecan. Conditions listed: Metastatic Triple Negative Breast Cancers. Triple-negative eligibility wording from the registry: \"Histologically and/or cytologically confirmed metastatic triple-negative breast cancer defined by estrogen receptor (ER) expression \\<10%, progesterone receptor expression \\<10% and HER2-negative status, defined by 0, 1+ or 2+ FISH negative by immunohistochemistry (IHC) by standard pathology\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07458113","url":"https://clinicaltrials.gov/study/NCT07458113"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic","brain-metastases"],"sections":[],"technologies":["adc"],"targets":[],"drugs":["sacituzumab-tirumotecan"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07458113","phase":"2","setting":"Sacituzumab Tirumotecan to Treat Patients With Brain Metastases From Triple-negative Breast Cancer","sponsor":"Yale University","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07458113/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"term":[{"id":"brain-metastases","kind":"term","name":"Brain metastases (intracranial disease)","route":"/terms/brain-metastases/"},{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}],"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"drug":[{"id":"sacituzumab-tirumotecan","kind":"drug","name":"Sacituzumab tirumotecan","route":"/drugs/sacituzumab-tirumotecan/"}]}}