{"entity":{"id":"nct07458529","kind":"trial","name":"Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer","aka":["NCRIT-PM9"],"tldr":"A phase 2 trial in colorectal cancer, run by Seventh Medical Center of PLA General Hospital, now recruiting.","summary":"Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07458529 by Seventh Medical Center of PLA General Hospital, with a registry enrolment figure of 50 participants, started 2026-02-10 and due to reach its primary completion in 2027-05-05. Interventions recorded: CRT+PD-1 inhibitor+Probio-M9; CRT+PD-1 inhibitor+placebo. Conditions listed: Rectal Cancer, Adenocarcinoma; Neoadjuvant Therapy; Immunotherapy; Probio-M9; Tislelizumab; Randomized. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: \"* Biopsy-proven rectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07458529","url":"https://clinicaltrials.gov/study/NCT07458529"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07458529","phase":"2","setting":"Neoadjuvant Chemoradiotherapy Combined With Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Middle and Low Rectal Cancer: A Single-Center, Prospective, Randomized Controlled Trial (NCRIT-PM9 Trial)","sponsor":"Seventh Medical Center of PLA General Hospital","enrolled":50,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07458529/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}