{"entity":{"id":"nct07463599","kind":"trial","name":"Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by HonorHealth Research Institute, now recruiting.","summary":"Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma is a phase 1/2, interventional study registered as NCT07463599 by HonorHealth Research Institute, with a registry enrolment figure of 126 participants, started 2026-02-17 and due to reach its primary completion in 2029-01. Interventions recorded: Tegavivint. Conditions listed: Metastatic Colorectal Carcinoma (mCRC); Colorectal Cancer (CRC); Adenomatous Polyposis Coli (APC) Gene Mutation; Catenin Beta-1 (CTNNB1) Gene Mutation. Primary outcome: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]; Maximum Tolerated Dose (MTD)/Administered Dose. Colorectal eligibility wording from the registry: \"Histologically and/or cytologically documented metastatic colorectal adenocarcinoma (all other histological types are excluded)\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07463599","url":"https://clinicaltrials.gov/study/NCT07463599"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07463599","phase":"1/2","setting":"A Phase 1/2, Dose Escalation and Expansion Trial to Evaluate the Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma","sponsor":"HonorHealth Research Institute","enrolled":126,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07463599/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}