{"entity":{"id":"nct07467590","kind":"trial","name":"Combination of High and Low-Dose Radiotherapy With Immune Therapy and TKI in Advanced Colorectal Cancer: A Phase II Study","aka":["TRIUNITE-07"],"tldr":"A phase 2 trial in colorectal cancer, run by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, not yet recruiting.","summary":"Combination of High and Low-Dose Radiotherapy With Immune Therapy and TKI in Advanced Colorectal Cancer: A Phase II Study is a phase 2, interventional study registered as NCT07467590 by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, with a registry enrolment figure of 33 participants, started 2026-04-01 and due to reach its primary completion in 2028-04-01. Interventions recorded: High- and Low-Dose Radiotherapy; Anti-Angiogenic TKI and Anti-PD-1 Therapy. Conditions listed: Refractory Colorectal Cancer; Radiotherapy-Induced Immune Priming; Immune Response. Primary outcome: Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"Histologically confirmed microsatellite stable (MSS) / proficient mismatch repair (pMMR) colorectal adenocarcinoma\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07467590","url":"https://clinicaltrials.gov/study/NCT07467590"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07467590","phase":"2","setting":"Efficacy of Combined High and Low-Dose Radiotherapy With Immune Therapy and Tyrosine Kinase Inhibitors (TKI) as a Second-Line or Later Treatment Strategy for Advanced Colorectal Cancer: A Single-Arm, Open-Label Phase II Study","sponsor":"Daping Hospital and the Research Institute of Surgery of the Third Military Medical University","enrolled":33,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07467590/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}