{"entity":{"id":"nct07485452","kind":"trial","name":"Boosting Osimertinib Blood Brain Barrier Penetration","aka":["OSIBBBOOST"],"tldr":"A phase 2 trial in lung cancer, run by Maastricht University Medical Center, now recruiting.","summary":"Boosting Osimertinib Blood Brain Barrier Penetration is a phase 2, interventional study registered as NCT07485452 by Maastricht University Medical Center, with a registry enrolment figure of 7 participants, started 2026-06 and due to reach its primary completion in 2027-06. Interventions recorded: Osimertinib & febuxostat. Conditions listed: Non-Small Cell Lung Cancer. Primary outcome: Effect of combining osimertinib with febuxostat on osimertinib CSF:plasma ratio in patients with EGFR NSCLC without CNS metastases. Lung eligibility wording from the registry: \"The patient has metastatic EGFR-mutated NSCLC and is treated with osimertinib as part of regular care with CT-confirmed stable disease or better\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07485452","url":"https://clinicaltrials.gov/study/NCT07485452"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["astrazeneca"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07485452","phase":"2","setting":"Boosting Osimertinib Blood Brain Barrier Penetration in Patients With Epidermal Growth Factor Receptor Mutated Non-small Cell Lung Cancer","sponsor":"Maastricht University Medical Center","enrolled":7,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07485452/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"company":[{"id":"astrazeneca","kind":"company","name":"AstraZeneca","route":"/companies/astrazeneca/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}