{"entity":{"id":"nct07503639","kind":"trial","name":"Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of retlirafusp alfa, SHR-8068, cAPOX (capecitabine, oxaliplatin) and cetuximab in colorectal cancer, run by Fudan University, not yet recruiting.","summary":"Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07503639 by Fudan University, with a registry enrolment figure of 134 participants, started 2026-04 and due to reach its primary completion in 2028-04. Interventions recorded: SHR-1701; SHR-8068; Short-course radiotherapy; XELOX (Capecitabine and Oxaliplatin); PD-L1 antibody; cetuximab β; HRS-7058; HRS-4642. Conditions listed: Locally Advanced Colorectal Cancer. Primary outcome: Complete response (CR) rate: rate of complete response (CR), including the rate of pathologic complete response (pCR) after surgery and the rate of cCR with W&W strategy.. Colorectal eligibility wording from the registry: \"Stage II/III colon cancer, or stage II/III rectal cancer located less than 10 cm from the anal verge;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07503639","url":"https://clinicaltrials.gov/study/NCT07503639"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt","monoclonal-antibody","platinum"],"targets":[],"drugs":["retlirafusp-alfa","shr-8068","capox","cetuximab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07503639","phase":"2","setting":"An Exploratory Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer Based on Molecular Subtypes","sponsor":"Fudan University","enrolled":134,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07503639/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"retlirafusp-alfa","kind":"drug","name":"Retlirafusp alfa","route":"/drugs/retlirafusp-alfa/"},{"id":"shr-8068","kind":"drug","name":"SHR-8068","route":"/drugs/shr-8068/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}