{"entity":{"id":"nct07523555","kind":"trial","name":"Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies","aka":[],"tldr":"A phase 1/2 trial of Autologous CD19/CD22 dual-target CAR-T module in acute lymphoblastic leukaemia, non-Hodgkin lymphoma, multiple myeloma, acute myeloid leukaemia and peripheral T-cell lymphomas, run by Beijing Biotech, now recruiting.","summary":"Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies is a phase 1/2 interventional study registered as NCT07523555 by Beijing Biotech, with 96 participants planned, started 2026-03-02 and due to reach its primary completion in 2027-03-14. Interventions recorded: Autologous CD19/CD22 dual-target CAR-T module, Autologous CD19/CD20 dual-target CAR-T module, Autologous BCMA/CD19 dual-target CAR-T module, Autologous BCMA/CD38 dual-target CAR-T module, Autologous BCMA/GPRC5D dual-target CAR-T and Autologous CD33/CD123 dual-target CAR-T module.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07523555","url":"https://clinicaltrials.gov/study/NCT07523555"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["all-leukemia","non-hodgkin-lymphoma","multiple-myeloma","aml","peripheral-t-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT07523555","phase":"1/2","setting":"A Phase 1/2, Open-Label, Nonrandomized, Multi-arm Umbrella Study of Biomarker-Selected Dual-Target CAR-T Cell Modules in Adults With Relapsed or Refractory Hematologic Malignancies","sponsor":"Beijing Biotech","enrolled":96,"outcomes":[]},"route":"/trials/nct07523555/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"peripheral-t-cell-lymphoma","kind":"cancer","name":"Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma)","route":"/cancers/peripheral-t-cell-lymphoma/"}]}}