{"entity":{"id":"nct07550088","kind":"trial","name":"BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases","aka":[],"tldr":"A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by Darren Sigal, MD, now recruiting.","summary":"BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases is a phase 2, interventional study registered as NCT07550088 by Darren Sigal, MD, with a registry enrolment figure of 17 participants, started 2026-06-10 and due to reach its primary completion in 2028-09. Interventions recorded: Balstilimab (BAL); Botensilimab (BOT); agenT-797. Conditions listed: Colorectal Cancer Metastatic. Primary outcome: Overall Response Rate (ORR). Colorectal eligibility wording from the registry: \"* Adults ≥18 years of age with histologically confirmed metastatic colorectal cancer with liver metastases, including evidence of active liver disease if previously treated locally\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07550088","url":"https://clinicaltrials.gov/study/NCT07550088"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["balstilimab","botensilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07550088","phase":"2","setting":"A Single-Arm, Phase II Study Evaluating Combination Balstilimab Plus Botensilimab With AgenT-797 in Previously Treated Patients With pMMR Metastatic CRC With Liver Metastases","sponsor":"Darren Sigal, MD","enrolled":17,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07550088/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"balstilimab","kind":"drug","name":"Balstilimab","route":"/drugs/balstilimab/"},{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}