{"entity":{"id":"nct07551414","kind":"trial","name":"Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI","aka":[],"tldr":"A phase 2 trial in lung cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, not yet recruiting.","summary":"Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI is a phase 2, interventional study registered as NCT07551414 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 38 participants, started 2026-05-30 and due to reach its primary completion in 2027-05-30. Interventions recorded: Zorifertinib Plus Intra-Ommaya CSF Chemotherapy. Conditions listed: NSCLC (Non-small Cell Lung Carcinoma); Leptomeningeal Metastasis; EGFR-TKI Sensitizing Mutation; Zorifertinib. Primary outcome: Response Assessment in Neuro - Oncology Leptomeningeal Metastases (RANO - LM) criteria. Lung eligibility wording from the registry: \"During the screening phase, subjects must be diagnosed with non-small cell lung cancer (NSCLC) and test positive for EGFR-sensitive mutations (L858R and/or Exon 19Del)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07551414","url":"https://clinicaltrials.gov/study/NCT07551414"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["egfr-mutant-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07551414","phase":"2","setting":"A Prospective Study of Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI Therapy","sponsor":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","enrolled":38,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07551414/","neighbours":{"cancer":[{"id":"egfr-mutant-nsclc","kind":"cancer","name":"EGFR-mutated non-small-cell lung cancer","route":"/cancers/egfr-mutant-nsclc/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}