{"entity":{"id":"nct07554859","kind":"trial","name":"GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 2 trial in lung cancer, run by Genfleet Therapeutics (Shanghai) Inc., not yet recruiting.","summary":"GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung Cancer is a phase 2, randomised interventional study registered as NCT07554859 by Genfleet Therapeutics (Shanghai) Inc., with a registry enrolment figure of 90 participants, started 2026-05-20 and due to reach its primary completion in 2027-04-30. Interventions recorded: ArmA:GFH375; Arm B:GFH375; Arm C:GFH375. Conditions listed: NSCLC (Advanced Non-small Cell Lung Cancer). Primary outcome: the efficacy of GFH375 as monotherapy and in combination therapy. Lung eligibility wording from the registry: \"Pathologically (histologically or cytologically) confirmed advanced (Stage IV) or locally advanced non-squamous non-small cell lung cancer that is not amenable to radical surgery or radiotherapy\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07554859","url":"https://clinicaltrials.gov/study/NCT07554859"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["genfleet"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07554859","phase":"2","setting":"A Multicenter, Open-label, Randomized Clinical Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of GFH375 Monotherapy and Combination Therapy as First-line Treatment in Patients With Advanced Non-small Cell Lung Cancer Harboring KRAS G12D Mutation.","sponsor":"Genfleet Therapeutics (Shanghai) Inc.","enrolled":90,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07554859/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"company":[{"id":"genfleet","kind":"company","name":"GenFleet Therapeutics","route":"/companies/genfleet/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}