{"entity":{"id":"nct07576725","kind":"trial","name":"Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial","aka":[],"tldr":"A phase 2 trial of nivolumab in colorectal cancer, run by Fred Hutchinson Cancer Center, not yet recruiting.","summary":"Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial is a phase 2, interventional study registered as NCT07576725 by Fred Hutchinson Cancer Center, with a registry enrolment figure of 50 participants, started 2026-12-01 and due to reach its primary completion in 2029-08-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Magnetic Resonance Imaging; Nivolumab. Conditions listed: Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8; Hodgkin Lymphoma; Kaposi Sarcoma; Metastatic Acral Lentiginous Melanoma; Metastatic Basal Cell Carcinoma; Metastatic Cervical Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Cutaneous Melanoma; Metastatic Head and Neck Squamous Cell Carcinoma; Metastatic Kaposi Sarcoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Merkel Cell Carcinoma; Metastatic Mucosal Melanoma; Metastatic Skin Squamous Cell Carcinoma; Metastatic Urothelial Carcinoma; Stage III Cervical Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8; Stage III Lung Cancer AJCC v8; Stage III Renal Cell Cancer AJCC v8; Stage IV Cervical Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Unresectable Acral Lentiginous Melanoma; Unresectable Basal Cell Carcinoma; Unresectable Cervical Carcinoma; Unresectable Clear Cell Renal Cell Carcinoma; Unresectable Colorectal Carcinoma; Unresectable Cutaneous Melanoma; Unresectable Head and Neck Squamous Cell Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Malignant Solid Neoplasm; Unresectable Merkel Cell Carcinoma; Unresectable Mucosal Melanoma; Unresectable Skin Squamous Cell Carcinoma; Unresectable Urothelial Carcinoma. Primary outcome: Objective response. Colorectal eligibility wording from the registry: \"* Colorectal cancer with high microsatellite instability (MSI) or mismatch repair deficiency\". Sites: Uganda. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07576725","url":"https://clinicaltrials.gov/study/NCT07576725"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["nivolumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07576725","phase":"2","setting":"AFFORD IO: A Phase 2 Trial of Low Dose, Reduced Frequency Nivolumab (Anti-PD-1 Antibody) in Patients With Unresectable or Metastatic Cancer","sponsor":"Fred Hutchinson Cancer Center","enrolled":50,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07576725/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}