{"entity":{"id":"nct07581626","kind":"trial","name":"Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Chinese PLA General Hospital, not yet recruiting.","summary":"Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07581626 by Chinese PLA General Hospital, with a registry enrolment figure of 60 participants, started 2026-05-01 and due to reach its primary completion in 2027-04-01. Interventions recorded: SCRT+targeted therapy+immunotherapy+chemotherapy. Conditions listed: Locally Advanced Rectal Cancer (LARC). Primary outcome: Complete Response (CR). Colorectal eligibility wording from the registry: \"* Middle or low rectal cancer located ≤10 cm from the anal verge as assessed by MRI\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07581626","url":"https://clinicaltrials.gov/study/NCT07581626"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07581626","phase":"2","setting":"A Single-Arm, Phase 2 Clinical Study on the Efficacy and Safety of Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer","sponsor":"Chinese PLA General Hospital","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07581626/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}