{"entity":{"id":"nct07596290","kind":"trial","name":"Yang et al. Anti-PD-1/CTLA-4 Dual Immunotherapy for LARC","aka":["RADICAL"],"tldr":"A phase 2/3 trial in colorectal cancer, run by Beijing Friendship Hospital, not yet recruiting.","summary":"Yang et al. Anti-PD-1/CTLA-4 Dual Immunotherapy for LARC is a phase 2/3, randomised interventional study registered as NCT07596290 by Beijing Friendship Hospital, with a registry enrolment figure of 342 participants, started 2026-07-15 and due to reach its primary completion in 2028-12-31. Interventions recorded: Short-course radiotherapy; Long-course radiotherapy; Immunotherapy. Conditions listed: Locally Advanced Rectal Adenocarcinoma; Neoadjuvant Chemoradiation; Neoadjuvant Immunotherapy. Primary outcome: Complete response. Colorectal eligibility wording from the registry: \"Histopathologically confirmed rectal adenocarcinoma via colonoscopy; pMMR or MSS phenotype;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07596290","url":"https://clinicaltrials.gov/study/NCT07596290"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07596290","phase":"2/3","setting":"Efficacy and Safety of Neoadjuvant Short-Course/Long-Course Radiotherapy Combined With Anti-PD-1/CTLA-4 Dual Immunotherapy for Locally Advanced Rectal Cancer: A Prospective, Randomized Controlled Trial (RADICAL Trial)","sponsor":"Beijing Friendship Hospital","enrolled":342,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07596290/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}