{"entity":{"id":"nct07644286","kind":"trial","name":"A Phase II Study of Pirfenidone Plus PD-1 Inhibitor With or Without Hypofractionated Radiotherapy for Refractory pMMR/MSS Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Tao Zhang, now recruiting.","summary":"A Phase II Study of Pirfenidone Plus PD-1 Inhibitor With or Without Hypofractionated Radiotherapy for Refractory pMMR/MSS Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07644286 by Tao Zhang, with a registry enrolment figure of 48 participants, started 2025-12-01 and due to reach its primary completion in 2027-01-25. Interventions recorded: Pirfenidone in combination with a PD-1 inhibitor; hypofractionated radiotherapy. Conditions listed: Colorectal Cancer (CRC). Primary outcome: Progression Free Survival（PFS）. Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed, unresectable locally advanced or metastatic pMMR/MSS colorectal cancer\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07644286","url":"https://clinicaltrials.gov/study/NCT07644286"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07644286","phase":"2","setting":"Phase II Study Evaluating the Safety, Tolerability, and Efficacy of Pirfenidone and PD-1 Inhibitor With or Without Hypofractionated Radiotherapy in Patients With Advanced, Refractory pMMR/MSS Colorectal Cancer","sponsor":"Tao Zhang","enrolled":48,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07644286/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}