{"entity":{"id":"nct07645118","kind":"trial","name":"Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer","aka":["IMPERIA"],"tldr":"A phase 2 trial of nivolumab in colorectal cancer, run by Dr. Te Vuong, not yet recruiting.","summary":"Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer is a phase 2, interventional study registered as NCT07645118 by Dr. Te Vuong, with a registry enrolment figure of 10 participants, started 2026-07 and due to reach its primary completion in 2028-12. Interventions recorded: Nivolumab; HDRBET; Total Mesorectal Excision (TME). Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: Pathologic complete response (pCR). Colorectal eligibility wording from the registry: \"Histologically confirmed rectal adenocarcinoma arising within 5 to 15 cm of the anal verge as measured by sigmoidoscopy or MRI\". Sites: Canada. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07645118","url":"https://clinicaltrials.gov/study/NCT07645118"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["nivolumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07645118","phase":"2","setting":"Pilot Evaluation of the Immunogenic Potentiation of Neo-adjuvant Brachytherapy Followed by Nivolumab Immunotherapy Without Chemotherapy in Stage II/III Locally Advanced Mismatch Repair Proficient Rectal Cancer","sponsor":"Dr. Te Vuong","enrolled":10,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07645118/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}