{"entity":{"id":"nct07646639","kind":"trial","name":"Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC","aka":["PRIDE-02"],"tldr":"A phase 2 trial in colorectal cancer, run by The First Affiliated Hospital with Nanjing Medical University, now recruiting.","summary":"Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC is a phase 2, randomised interventional study registered as NCT07646639 by The First Affiliated Hospital with Nanjing Medical University, with a registry enrolment figure of 122 participants, started 2026-05-20 and due to reach its primary completion in 2028-12-31. Interventions recorded: Sintilimab + IL-2 Combined with CAPOX; Short-course low-dose radiotherapy; Short-course standard-dose radiotherapy. Conditions listed: Rectal Cancer; Radiotherapy. Primary outcome: Complete remission. Colorectal eligibility wording from the registry: \"Histologically confirmed rectal adenocarcinoma with the distal margin of the tumor located within 12 cm of the anal verge\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07646639","url":"https://clinicaltrials.gov/study/NCT07646639"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07646639","phase":"2","setting":"Different-Dose Short-Course Radiotherapy Plus CAPOX, Anti-PD-1 Antibody and Interleukin-2 for Locally Advanced Rectal Cancer: A Single-Centre, Prospective, Randomised Phase II Trial","sponsor":"The First Affiliated Hospital with Nanjing Medical University","enrolled":122,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07646639/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}