{"entity":{"id":"nct07651007","kind":"trial","name":"Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Wang Xin, not yet recruiting.","summary":"Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR is a phase 2, interventional study registered as NCT07651007 by Wang Xin, with a registry enrolment figure of 29 participants, started 2026-05-31 and due to reach its primary completion in 2027-12-31. Interventions recorded: iTNT-HX02. Conditions listed: Advanced Rectal Cancer. Primary outcome: Complete response rate. Colorectal eligibility wording from the registry: \"Pathologically confirmed rectal adenocarcinoma with immunohistochemistry and/or genetic testing showing MSS/pMMR status;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07651007","url":"https://clinicaltrials.gov/study/NCT07651007"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07651007","phase":"2","setting":"A Phase II Clinical Study of Short-course Radiotherapy Followed by NALIRIFOX Plus Pemolivimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR","sponsor":"Wang Xin","enrolled":29,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07651007/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}