{"entity":{"id":"nct07656376","kind":"trial","name":"Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation","aka":[],"tldr":"A phase 2/3 trial in pancreatic cancer, run by Jiangxi Kvvit Pharmaceutical Co., Ltd., not yet recruiting.","summary":"Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation is a phase 2/3, randomised interventional study registered as NCT07656376 by Jiangxi Kvvit Pharmaceutical Co., Ltd., with a registry enrolment figure of 465 participants, started 2027-06-06 and due to reach its primary completion in 2029-02-07. Interventions recorded: DN022150+AG( Stage I ）; DN022150+AG（Stage II）; placebo+AG（Stage II）. Conditions listed: Pancreatic Cancer; Pancreatic Carcinoma. Primary outcome: DLT; PFS as assessed by BICR per RECIST 1.1; OS. Pancreatic eligibility wording from the registry: \"Subjects with confirmed KRAS G12D who have not received prior systemic antineoplastic therapy for advanced or metastatic pancreatic cancer\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07656376","url":"https://clinicaltrials.gov/study/NCT07656376"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac","metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07656376","phase":"2/3","setting":"Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation","sponsor":"Jiangxi Kvvit Pharmaceutical Co., Ltd.","enrolled":465,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07656376/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"},{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}