{"entity":{"id":"nct07677579","kind":"trial","name":"NIMBLE-CRC: NeoImmunoModulation Before Leveraging Excision in Colorectal Rectal Cancer","aka":["NIMBLE"],"tldr":"A phase 2 trial of retifanlimab and zanzalintinib in colorectal cancer, run by Northwell Health, not yet recruiting.","summary":"NIMBLE-CRC: NeoImmunoModulation Before Leveraging Excision in Colorectal Rectal Cancer is a phase 2, interventional study registered as NCT07677579 by Northwell Health, with a registry enrolment figure of 26 participants, started 2026-08-30 and due to reach its primary completion in 2028-08-30. Interventions recorded: Retifanlimab; Zanzalintinib. Conditions listed: Colon Cancer Metastatic. Primary outcome: Intent for Curative Surgery Post-Treatment. Colorectal eligibility wording from the registry: \"* Histological-confirmed adenocarcinoma of the colon that is amenable to curative intent resection\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07677579","url":"https://clinicaltrials.gov/study/NCT07677579"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["retifanlimab","zanzalintinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07677579","phase":"2","setting":"NIMBLE-CRC: NeoImmunoModulation Before Leveraging Excision in Colorectal Rectal Cancer","sponsor":"Northwell Health","enrolled":26,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07677579/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"retifanlimab","kind":"drug","name":"Retifanlimab","route":"/drugs/retifanlimab/"},{"id":"zanzalintinib","kind":"drug","name":"Zanzalintinib","route":"/drugs/zanzalintinib/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}