{"entity":{"id":"nct07686640","kind":"trial","name":"Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer","aka":["SCRIT"],"tldr":"A phase 3 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.","summary":"Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07686640 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 180 participants, started 2026-08-15 and due to reach its primary completion in 2029-07-15. Interventions recorded: Short-Course Radiotherapy; Consolidation treatment (With ICIs); Consolidation treatment (Without ICIs). Conditions listed: Local Advanced Rectal Cancer; Radiotherapy; Immunotherapy. Primary outcome: Complete Response (CR) Rate. Colorectal eligibility wording from the registry: \"* Patients aged 18-75 years with histologically confirmed pMMR/MSS rectal adenocarcinoma are eligible if they have MRI-defined clinical stage II or III disease according to AJCC 8th edition, tumor located within 12 cm from the anal verge, and at least one high-risk feature, including cT4b, cN2, EMVI\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07686640","url":"https://clinicaltrials.gov/study/NCT07686640"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07686640","phase":"3","setting":"Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer (SCRIT): A Multicenter Phase III Randomized Controlled Trial","sponsor":"Shandong Cancer Hospital and Institute","enrolled":180,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07686640/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}