{"entity":{"id":"nct07689058","kind":"trial","name":"Home-made BCMA CAR-T cells for relapsed or refractory multiple myeloma (Rawalpindi pilot)","aka":[],"tldr":"A small Rawalpindi study of CAR-T cells made in Pakistan and aimed at a protein on myeloma cells, for adults whose myeloma has come back after other treatment.","summary":"Registered as phase 2 on ClinicalTrials.gov (first posted 8 July 2026), a pilot, open-label, single-arm study of autologous BCMA-directed CAR-T cells in adults with relapsed or refractory multiple myeloma. The primary outcome is safety, tolerability and the feasibility of manufacturing and delivering the product. Estimated enrolment is 10, with primary completion estimated for 31 December 2027; the principal investigator listed is Tariq Ghafoor, at the National University of Medical Sciences clinical trial unit in Rawalpindi. No results are posted.","status":"recruiting","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT07689058","url":"https://clinicaltrials.gov/study/NCT07689058"}],"tags":[],"related":[],"cancers":["multiple-myeloma"],"sections":[],"technologies":["car-t","point-of-care-cell-manufacturing"],"targets":["bcma"],"drugs":[],"companies":[],"institutions":["afbmtc-rawalpindi"],"pathways":[],"terms":["crs"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07689058","phase":"2","setting":"Pilot, Open-Label, Single-Arm Study of Autologous BCMA-Directed CAR-T Cells in Patients With Relapsed/Refractory Multiple Myeloma in Pakistan","sponsor":"National Institute of Blood and Marrow Transplant (NIBMT), Pakistan (sponsor-investigator Dr Zaineb Akram)","started":"2026-06-01","startedType":"actual","enrolled":10,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07689058/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"point-of-care-cell-manufacturing","kind":"technology","name":"Point-of-care and decentralised cell manufacturing","route":"/technologies/point-of-care-cell-manufacturing/"}],"target":[{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/"}],"institution":[{"id":"afbmtc-rawalpindi","kind":"institution","name":"Armed Forces Bone Marrow Transplant Centre, Rawalpindi","route":"/institutions/afbmtc-rawalpindi/"}],"term":[{"id":"crs","kind":"term","name":"Cytokine release syndrome (CRS)","route":"/terms/crs/"}]}}