{"entity":{"id":"nct07689643","kind":"trial","name":"Safety and Preliminary Efficacy of [177Lu]Lu-RTX-2358 Combined With Immune Checkpoint Inhibitors in Patients With FAP-positive Metastatic Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 1 trial of [Ac-225]RTX-2358 run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, now recruiting.","summary":"Safety and Preliminary Efficacy of [177Lu]Lu-RTX-2358 Combined With Immune Checkpoint Inhibitors in Patients With FAP-positive Metastatic Non-Small Cell Lung Cancer is a phase 1 interventional study registered as NCT07689643 by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, with 36 participants planned, started 2026-04-28. Conditions recorded: Metastatic Non-small Cell Lung Cancer. Interventions recorded: [177Lu]Lu-RTX-2358.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07689643","url":"https://clinicaltrials.gov/study/NCT07689643"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["rtx-2358"],"companies":["ratio-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07689643","phase":"1","setting":"A Single-Center, Prospective, Open-Label, Investigator-Initiated Study Evaluating the Safety, Biodistribution, Radiation Dosimetry, and Preliminary Efficacy of [177Lu]Lu-RTX-2358 Combined With Immune Checkpoint Inhibitors in Patients With FAP-positive Metastatic Non-Small Cell Lung Cancer","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","enrolled":36,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07689643/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"rtx-2358","kind":"drug","name":"[Ac-225]RTX-2358","route":"/drugs/rtx-2358/"}],"company":[{"id":"ratio-therapeutics","kind":"company","name":"Ratio Therapeutics","route":"/companies/ratio-therapeutics/"}]}}