{"entity":{"id":"nct07691489","kind":"trial","name":"A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Memorial Sloan Kettering Cancer Center, not yet recruiting.","summary":"A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer is a phase 2, interventional study registered as NCT07691489 by Memorial Sloan Kettering Cancer Center, with a registry enrolment figure of 27 participants, started 2026-08 and due to reach its primary completion in 2029-06. Interventions recorded: Fam-Trastuzumab Deruxtecan-Nxki. Conditions listed: Colorectal Cancer; Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum. Primary outcome: Overall Response Rate (ORR). Colorectal eligibility wording from the registry: \"* Have histologically confirmed adenocarcinoma of the colon or rectum that is metastatic and/or unresectable\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07691489","url":"https://clinicaltrials.gov/study/NCT07691489"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","her2-amplified-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["astrazeneca"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07691489","phase":"2","setting":"A Phase 2 Trial of Trastuzumab Deruxtecan in Combination With Cetuximab in HER2-low Metastatic Colorectal Cancer That Has Progressed on Standard Therapies","sponsor":"Memorial Sloan Kettering Cancer Center","enrolled":27,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07691489/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"her2-amplified-colorectal","kind":"cancer","name":"HER2-amplified colorectal cancer","route":"/cancers/her2-amplified-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"company":[{"id":"astrazeneca","kind":"company","name":"AstraZeneca","route":"/companies/astrazeneca/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}