{"entity":{"id":"nct07691593","kind":"trial","name":"Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic Cancer","aka":[],"tldr":"A phase 2 trial in pancreatic cancer, run by Changhai Hospital, not yet recruiting.","summary":"Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic Cancer is a phase 2, interventional study registered as NCT07691593 by Changhai Hospital, with a registry enrolment figure of 60 participants, started 2026-06 and due to reach its primary completion in 2027-10. Interventions recorded: HRS-4642+NALIRIFOX; HRS-4642+NALIRIFOX+Adebrelimab; HRS-4642+NALIRIFOX+Adebrelimab. Conditions listed: Pancreatic Cancer. Primary outcome: Adverse events (AEs); Objective Response Rate (ORR) based on Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1). Pancreatic eligibility wording from the registry: \"Pathologically or cytologically confirmed ductal adenocarcinoma of the pancreas; and subjects must have at least one measurable lesion as defined by Response Evaluation Criteria in Solid Tumors (RECIST, version 1\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07691593","url":"https://clinicaltrials.gov/study/NCT07691593"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["resectable-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07691593","phase":"2","setting":"An Exploratory Clinical Study of HRS-4642 in Combination With Chemotherapy With or Without Adebrelimab as Neoadjuvant Therapy for Pancreatic Cancer","sponsor":"Changhai Hospital","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07691593/","neighbours":{"cancer":[{"id":"resectable-pdac","kind":"cancer","name":"Resectable pancreatic ductal adenocarcinoma","route":"/cancers/resectable-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}