{"entity":{"id":"nct07691632","kind":"trial","name":"Serplulimab Plus Decitabine and CAPOX Before Surgery for Locally Advanced Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Tianjin Medical University Cancer Institute and Hospital, not yet recruiting.","summary":"Serplulimab Plus Decitabine and CAPOX Before Surgery for Locally Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT07691632 by Tianjin Medical University Cancer Institute and Hospital, with a registry enrolment figure of 35 participants, started 2026-06-30 and due to reach its primary completion in 2027-12-31. Interventions recorded: Serplulimab + Decitabine + CAPOX (Oxaliplatin + Capecitabine). Conditions listed: Locally Advanced Colorectal Cancer; Colorectal Adenocarcinoma. Primary outcome: Pathological Complete Response Rate. Colorectal eligibility wording from the registry: \"* Histologically or pathologically confirmed colorectal adenocarcinoma with no prior antitumor treatment, staged as cT3/cT4N+M0 locally advanced colorectal cancer according to the AJCC/UICC 8th edition based on contrast-enhanced CT or MRI, with colonoscopy and/or diagnostic laparoscopy if clinically\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07691632","url":"https://clinicaltrials.gov/study/NCT07691632"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07691632","phase":"2","setting":"A Single-Arm, Single-Center, Phase II Exploratory Clinical Study of Serplulimab Combined With Decitabine Plus CAPOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer","sponsor":"Tianjin Medical University Cancer Institute and Hospital","enrolled":35,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07691632/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}