{"entity":{"id":"nct07698106","kind":"trial","name":"Enhancing ICB Efficacy Through IL-1 Inhibition in TNBC","aka":[],"tldr":"A phase 1/2 trial in triple-negative breast cancer, run by University Health Network, Toronto, not yet recruiting.","summary":"Enhancing ICB Efficacy Through IL-1 Inhibition in TNBC is a phase 1/2, randomised interventional study registered as NCT07698106 by University Health Network, Toronto, with a registry enrolment figure of 60 participants, started 2026-08 and due to reach its primary completion in 2034-08. Interventions recorded: Group 1-Isunakinra. Conditions listed: Triple-Negative Breast Cancer (TNBC). Triple-negative eligibility wording from the registry: \"Newly diagnosed, locally advanced, previously untreated and centrally confirmed TNBC, as defined by the most recent American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines, and staging per current AJCC staging criteria for breast cancer as assessed by the inves\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07698106","url":"https://clinicaltrials.gov/study/NCT07698106"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07698106","phase":"1/2","setting":"Rebooting Sensitivity to Checkpoint Blockade Therapy in Triple-Negative Breast Cancer With Isunakinra (RESETT- I)","sponsor":"University Health Network, Toronto","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07698106/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}