{"entity":{"id":"nct07711067","kind":"trial","name":"A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer","aka":["MATTERS-2"],"tldr":"A phase 2/3 trial in pancreatic cancer, run by ElmediX, not yet recruiting.","summary":"A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer is a phase 2/3, randomised interventional study registered as NCT07711067 by ElmediX, with a registry enrolment figure of 95 participants, started 2026-10-01 and due to reach its primary completion in 2030-03-31. Interventions recorded: Whole-body hyperthermia; Standard-of-Care Systemic therapy. Conditions listed: Pancreatic Ductal Adenocarcinoma (mPDAC); Metastatic Pancreatic Ductal Adenocarcinoma (PDAC). Primary outcome: Overall survival (OS); Safety and tolerability of WBHT + SoC and SoC alone. Pancreatic eligibility wording from the registry: \"Subjects with metastatic pancreatic adenocarcinoma (PDAC) confirmed by histology\". Sites: Belgium, Spain. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07711067","url":"https://clinicaltrials.gov/study/NCT07711067"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07711067","phase":"2/3","setting":"A Multi-Centric, Randomized, Pivotal Study, Evaluating Efficacy and Safety of Whole-Body Hyperthermia Alongside Standard Systemic Anticancer Therapy in Patients With Metastatic Pancreatic Cancer After Failure of First Line Treatment.","sponsor":"ElmediX","enrolled":95,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07711067/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}