{"entity":{"id":"nct07714447","kind":"trial","name":"Efficacy and Safety of Tunlametinib Combination Therapy in the Treatment of Second-line and Above Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.","summary":"Efficacy and Safety of Tunlametinib Combination Therapy in the Treatment of Second-line and Above Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07714447 by Sun Yat-sen University, with a registry enrolment figure of 91 participants, started 2026-11-30 and due to reach its primary completion in 2029-02-01. Interventions recorded: Arm1; Arm 2; Arm 3. Conditions listed: CRC (Colorectal Cancer); BRAF. Primary outcome: Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"* Patients with metastatic colorectal cancer confirmed by histology or cytology\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07714447","url":"https://clinicaltrials.gov/study/NCT07714447"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07714447","phase":"2","setting":"Efficacy and Safety of Tunlametinib Combination Therapy in the Treatment of Second-line and Above Metastatic Colorectal Cancer: a Multicentre, Multicohort, Phase 2 Trial.","sponsor":"Sun Yat-sen University","enrolled":91,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07714447/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}