{"entity":{"id":"nct07723703","kind":"trial","name":"Phase 1 Open-label Study of AMX-883 Alone in Participants With AML and High-risk MDS and in Combination in Participants With AML","aka":[],"tldr":"A phase 1 trial of AMX-883 run by Amphista Therapeutics Ltd, now recruiting.","summary":"Phase 1 Open-label Study of AMX-883 Alone in Participants With AML and High-risk MDS and in Combination in Participants With AML is a phase 1 interventional study registered as NCT07723703 by Amphista Therapeutics Ltd, with 54 participants planned, started 2026-09-16. Conditions recorded: Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome. Interventions recorded: AMX-883 and Posaconazole.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07723703","url":"https://clinicaltrials.gov/study/NCT07723703"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["aml","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["amx-883"],"companies":["amphista-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07723703","phase":"1","setting":"A Phase 1, Open-Label, Multi-Centre Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of AMX-883 Monotherapy in Participants With Acute Myeloid Leukaemia and High-Risk Myelodysplastic Syndrome and in Combination With Anticancer Agents in Participants With Acute Myeloid Leukaemia","sponsor":"Amphista Therapeutics Ltd","enrolled":54,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07723703/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"amx-883","kind":"drug","name":"AMX-883","route":"/drugs/amx-883/"}],"company":[{"id":"amphista-therapeutics","kind":"company","name":"Amphista Therapeutics","route":"/companies/amphista-therapeutics/"}]}}