{"entity":{"id":"nct07737600","kind":"trial","name":"A Study of MRG007 Combination Therapy for Advanced Colorectal Cancer","aka":[],"tldr":"A phase 1/2 trial of fluorouracil (5-FU), leucovorin (folinic acid), bevacizumab (glioblastoma use), fOLFOX (5-FU, leucovorin, oxaliplatin) and other drugs in colorectal cancer, run by Lepu Biopharma Co., Ltd., not yet recruiting.","summary":"A Study of MRG007 Combination Therapy for Advanced Colorectal Cancer is a phase 1/2, interventional study registered as NCT07737600 by Lepu Biopharma Co., Ltd., with a registry enrolment figure of 316 participants, started 2026-08 and due to reach its primary completion in 2028-12. Interventions recorded: MRG007; 5-Fluorouracil / Leucovorin Calcium; Bevacizumab; Oxaliplatin; PD-1/VEGF antibody; Capecitabine. Conditions listed: Advanced Colorectal Cancer. Primary outcome: Dose Limiting Toxicity (DLT); Serious Adverse Events (SAEs); Adverse Event (AE). Colorectal eligibility wording from the registry: \"Pathologically confirmed, unresectable locally advanced or metastatic colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07737600","url":"https://clinicaltrials.gov/study/NCT07737600"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["fluorouracil","leucovorin","bevacizumab-glioma","folfox","capecitabine"],"companies":["lepu-biopharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07737600","phase":"1/2","setting":"Phase Ib/II Clinical Study of the Safety, Tolerability, Pharmacokinetics, and Efficacy of MRG007 Combination Therapy in Patients With Advanced Colorectal Cancer","sponsor":"Lepu Biopharma Co., Ltd.","enrolled":316,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07737600/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"bevacizumab-glioma","kind":"drug","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/"},{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"fluorouracil","kind":"drug","name":"Fluorouracil (5-FU)","route":"/drugs/fluorouracil/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"},{"id":"leucovorin","kind":"drug","name":"Leucovorin (folinic acid)","route":"/drugs/leucovorin/"}],"company":[{"id":"lepu-biopharma","kind":"company","name":"Lepu Biopharma","route":"/companies/lepu-biopharma/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}