{"entity":{"id":"nct07750951","kind":"trial","name":"Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally A","aka":["sintilimab"],"tldr":"A phase 2 trial in colorectal cancer, run by Xijing Hospital, now recruiting.","summary":"Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07750951 by Xijing Hospital, with a registry enrolment figure of 34 participants, started 2026-05-29 and due to reach its primary completion in 2026-11. Interventions recorded: Cindilimab、IBI310、Capecitabine、Oxaliplatin. Conditions listed: MSI-H/dMMR Locally Advanced Rectal Adenocarcinoma. Primary outcome: Pathological complete response (PCR) rate. Colorectal eligibility wording from the registry: \"* 4\\) The primary lesion is a locally advanced rectal adenocarcinoma with histopathologically confirmed MSI-H/dMMR characteristics\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07750951","url":"https://clinicaltrials.gov/study/NCT07750951"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07750951","phase":"2","setting":"Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer","sponsor":"Xijing Hospital","enrolled":34,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07750951/","neighbours":{"cancer":[{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}