{"entity":{"id":"nct07752875","kind":"trial","name":"A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation","aka":[],"tldr":"A phase 1/2 trial in pancreatic cancer, run by LG Chem, not yet recruiting.","summary":"A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation is a phase 1/2, interventional study registered as NCT07752875 by LG Chem, with a registry enrolment figure of 250 participants, started 2026-12-01 and due to reach its primary completion in 2032-10-31. Interventions recorded: LG00313112. Conditions listed: Ovarian Cancer; Small Cell Lung Cancer; Non Small Cell Lung Cancer; Colorectal Cancer; Esophageal Cancer; Breast Cancer; Endometrial Cancer; Head and Neck Cancer; Pancreatic Cancer; Locally Advanced Unresectable or Metastatic Solid Tumor. Primary outcome: Phase 1: Number of participants with dose-limiting toxicities (DLTs); Phase 1: Frequency of treatment-emergent adverse events (TEAEs); Phase 1: Frequency of serious adverse events (SAEs). Pancreatic eligibility wording from the registry: \"Acute or chronic uncontrolled renal disease, pancreatitis, or liver disease\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07752875","url":"https://clinicaltrials.gov/study/NCT07752875"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac","metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07752875","phase":"1/2","setting":"A Phase 1/2, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation","sponsor":"LG Chem","enrolled":250,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07752875/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"},{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}