{"entity":{"id":"nct07784985","kind":"trial","name":"A Study of NST-628 in Recurrent Grade 4 Glioma","aka":[],"tldr":"A phase 1 trial of NST-628 run by Nader Sanai, not yet recruiting.","summary":"A Study of NST-628 in Recurrent Grade 4 Glioma is a phase 1 interventional study registered as NCT07784985 by Nader Sanai, with 12 participants planned, started 2026-10. Conditions recorded: Glioma, Recurrent High Grade and Grade 4 Malignant Glioma. Interventions recorded: NST-628.","status":"planned","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07784985","url":"https://clinicaltrials.gov/study/NCT07784985"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["brain-tumours","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["nst-628"],"companies":["nested-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07784985","phase":"1","setting":"A Phase 0/1 Study of NST-628 in Participants With Recurrent Grade 4 Glioma Scheduled for Resection to Evaluate Central Nervous System (CNS) Penetration With Pharmacodynamic (PD) Triggered Expansion Cohort","sponsor":"Nader Sanai","enrolled":12,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07784985/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"nst-628","kind":"drug","name":"NST-628","route":"/drugs/nst-628/"}],"company":[{"id":"nested-therapeutics","kind":"company","name":"Nested Therapeutics","route":"/companies/nested-therapeutics/"}]}}