{"entity":{"id":"nct07807800","kind":"trial","name":"A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC)","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by D. E. Shaw Research, LLC, not yet recruiting.","summary":"A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC) is a phase 1/2, randomised interventional study registered as NCT07807800 by D. E. Shaw Research, LLC, with a registry enrolment figure of 88 participants, started 2026-12-03 and due to reach its primary completion in 2028-07-02. Interventions recorded: DES-1357. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Part 1: Number of Participants With Dose-Limiting Toxicities (DLTs); Part 2: Incidence and Severity of Treatment- related Treatment Emergent Adverse Events (TEAEs) Through at least 3 Cycles of DES-1357; Part 2: Best Overall Response (BOR). Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed carcinoma of the colon and/or rectum deemed unresectable and/or with evidence of metastases, that has been cytologically or genetically confirmed as dMMR, and/or MSI-H\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07807800","url":"https://clinicaltrials.gov/study/NCT07807800"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07807800","phase":"1/2","setting":"A Phase 1/2 Adaptive Study of DES-1357 in Participants With Deficient Mismatch Repair (dMMR) and/or Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC)","sponsor":"D. E. Shaw Research, LLC","enrolled":88,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07807800/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}