{"entity":{"id":"nct07814248","kind":"trial","name":"A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors","aka":[],"tldr":"A phase 1 trial of TS-104 run by TwoStep Therapeutics, Inc., now recruiting.","summary":"A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors is a phase 1 interventional study registered as NCT07814248 by TwoStep Therapeutics, Inc., with 74 participants planned, started 2026-09-02. Conditions recorded: NSCLC (Non-small Cell Lung Cancer), HNSCC, Endometrial, Ovarian Cancer, Esophageal Cancer, Head & Neck Cancer, Gastric Cancer (GC) and Endometrial Cancer. Interventions recorded: TS-104.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07814248","url":"https://clinicaltrials.gov/study/NCT07814248"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc","head-and-neck","endometrial","ovarian","esophageal","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["ts-104"],"companies":["twostep-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07814248","phase":"1","setting":"A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Advanced Solid Tumors","sponsor":"TwoStep Therapeutics, Inc.","enrolled":74,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07814248/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"drug":[{"id":"ts-104","kind":"drug","name":"TS-104","route":"/drugs/ts-104/"}],"company":[{"id":"twostep-therapeutics","kind":"company","name":"TwoStep Therapeutics","route":"/companies/twostep-therapeutics/"}]}}