{"entity":{"id":"nct07816380","kind":"trial","name":"A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 3 trial in lung cancer, run by Guangzhou JOYO Pharma Co., Ltd, not yet recruiting.","summary":"A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT07816380 by Guangzhou JOYO Pharma Co., Ltd, with a registry enrolment figure of 216 participants, started 2026-10-30 and due to reach its primary completion in 2028-12-30. Interventions recorded: JYP0322 Tablets; Crizotinib Capsules. Conditions listed: NSCLC (Advanced Non-small Cell Lung Cancer). Primary outcome: Progression-Free Survival (PFS) assessed by Blinded Independent Central Review (BICR/BIRC) per RECIST v1.1. Lung eligibility wording from the registry: \"Histologically or cytologically confirmed, unresectable locally advanced (AJCC 9th edition stage IIIB or IIIC not amenable to multimodality therapy) or metastatic (stage IV) ROS1-positive non-small cell lung cancer (NSCLC)\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07816380","url":"https://clinicaltrials.gov/study/NCT07816380"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["ros1-positive-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07816380","phase":"3","setting":"A Randomized, Open-Label, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of JYP0322 Versus Crizotinib in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer","sponsor":"Guangzhou JOYO Pharma Co., Ltd","enrolled":216,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07816380/","neighbours":{"cancer":[{"id":"ros1-positive-nsclc","kind":"cancer","name":"ROS1-positive non-small-cell lung cancer","route":"/cancers/ros1-positive-nsclc/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}