{"entity":{"id":"nct07817888","kind":"trial","name":"mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer","aka":["FOBEAR-ii"],"tldr":"A phase 2 trial of FOLFOXIRI in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.","summary":"mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07817888 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 119 participants, started 2026-09-30 and due to reach its primary completion in 2028-09-30. Interventions recorded: FOLFOXIRI + Bevacizumab. Conditions listed: Phase 2 Study. Primary outcome: 3-year Disease Free Survival. Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07817888","url":"https://clinicaltrials.gov/study/NCT07817888"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum","topoisomerase-inhibitors"],"targets":[],"drugs":["folfoxiri"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07817888","phase":"2","setting":"Neoadjuvant mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer: A Singe-arm Phase II Study","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":119,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07817888/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"drug":[{"id":"folfoxiri","kind":"drug","name":"FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)","route":"/drugs/folfoxiri/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}