{"entity":{"id":"nct07874880","kind":"trial","name":"MTX-531-001 Phase 1 Study in Advanced Solid Tumors","aka":[],"tldr":"A phase 1 trial of MTX-531 run by MEKanistic Therapeutics, Inc., not yet recruiting.","summary":"MTX-531-001 Phase 1 Study in Advanced Solid Tumors is a phase 1 interventional study registered as NCT07874880 by MEKanistic Therapeutics, Inc., with 71 participants planned, started 2026-10-20. Conditions recorded: Solid Tumors (Phase 1), HNSCC, Endometrial Cancer, Her2-negative Metastatic Breast Cancer, Pan-RAS and BRAF Wild-type Advanced, Metastatic Colorectal Cancer (CRC) and Head and Neck Squamous Cell Carcinoma. Interventions recorded: MTX-531.","status":"planned","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07874880","url":"https://clinicaltrials.gov/study/NCT07874880"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","head-and-neck","endometrial","breast-cancer","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["mtx-531"],"companies":["mekanistic-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07874880","phase":"1","setting":"First-in-Human, Phase 1, Open-label Study to Evaluate the Safety, Clinical Activity, Pharmacokinetics, and Pharmacodynamics of MTX-531, a Dual EGFR/PI3K Inhibitor, as Monotherapy in Adults With Advanced Solid Tumors","sponsor":"MEKanistic Therapeutics, Inc.","enrolled":71,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07874880/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"mtx-531","kind":"drug","name":"MTX-531","route":"/drugs/mtx-531/"}],"company":[{"id":"mekanistic-therapeutics","kind":"company","name":"MEKanistic Therapeutics","route":"/companies/mekanistic-therapeutics/"}]}}