{"entity":{"id":"nct07902037","kind":"trial","name":"A Study of SRN-101 Gene Therapy in Adults With Recurrent High-Grade Glioma (ALERT-1)","aka":[],"tldr":"A phase 1/2 trial of SRN-101 run by Siren Biotechnology, not yet recruiting.","summary":"A Study of SRN-101 Gene Therapy in Adults With Recurrent High-Grade Glioma (ALERT-1) is a phase 1/2 interventional study registered as NCT07902037 by Siren Biotechnology, with 40 participants planned, started 2026-12. Conditions recorded: Recurrent High Grade Gliomas, Glioblastoma (GBM), Astrocytoma, Oligodendroglioma and Diffuse Hemispheric Glioma. Interventions recorded: SRN-101.","status":"planned","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07902037","url":"https://clinicaltrials.gov/study/NCT07902037"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["brain-tumours","glioblastoma","oligodendroglioma"],"sections":[],"technologies":[],"targets":[],"drugs":["srn-101"],"companies":["siren-biotechnology"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07902037","phase":"1/2","setting":"A Phase 1/2, Dose-Escalation and Expansion Study to Evaluate the Safety, Tolerability, and Preliminary Anti-tumor Activity of SRN-101, a Recombinant Adeno-Associated Virus Immunotherapy in Adults With Recurrent High-Grade Glioma","sponsor":"Siren Biotechnology","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07902037/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"oligodendroglioma","kind":"cancer","name":"Oligodendroglioma, IDH-mutant and 1p/19q-codeleted","route":"/cancers/oligodendroglioma/"}],"drug":[{"id":"srn-101","kind":"drug","name":"SRN-101","route":"/drugs/srn-101/"}],"company":[{"id":"siren-biotechnology","kind":"company","name":"Siren Biotechnology","route":"/companies/siren-biotechnology/"}]}}