{"entity":{"id":"nct07912593","kind":"trial","name":"Phase 1/2, Open-label Study of ETX-929, a KRAS Inhibitor in Participants With Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of ETX-929 run by Ensem Therapeutics, now recruiting.","summary":"Phase 1/2, Open-label Study of ETX-929, a KRAS Inhibitor in Participants With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT07912593 by Ensem Therapeutics, with 320 participants planned, started 2026-10-22. Conditions recorded: Metastatic Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Non-squamous, Non-Small Cell Lung Cancer, Endometrial Adenocarcinoma, Ovarian Adenocarcinoma and Primary Peritoneal Carcinoma. Interventions recorded: ETX-929 dose escalation and ETX-929 dose escalation in combination with cetuximab.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07912593","url":"https://clinicaltrials.gov/study/NCT07912593"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal","pancreatic","nsclc","endometrial","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":["etx-929"],"companies":["ensem-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07912593","phase":"1/2","setting":"A Phase 1/2, First-in-Human Study of ETX-929, a Pan-KRAS Inhibitor, as Monotherapy and in Combination With Other Anticancer Therapies in Participants With KRAS-Altered Advanced Solid Tumors","sponsor":"Ensem Therapeutics","enrolled":320,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07912593/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"etx-929","kind":"drug","name":"ETX-929","route":"/drugs/etx-929/"}],"company":[{"id":"ensem-therapeutics","kind":"company","name":"Ensem Therapeutics","route":"/companies/ensem-therapeutics/"}]}}