{"entity":{"id":"ndufa13","kind":"target","name":"NDUFA13","aka":["NADH:ubiquinone oxidoreductase subunit A13","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","CGI-39","CDA016","GRIM-19","GRIM19","B16.6"],"tldr":"NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes clinical 0.67, genetic literature 0.61, literature 0.93, genetic association 0.59, animal model 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17194","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17194"},{"label":"UniProt Q9P0J0","url":"https://www.uniprot.org/uniprotkb/Q9P0J0/entry"},{"label":"NCBI Gene 51079","url":"https://www.ncbi.nlm.nih.gov/gene/51079"},{"label":"Ensembl ENSG00000186010","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186010"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NDUFA13","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:17194","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17194","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P0J0","url":"https://www.uniprot.org/uniprotkb/Q9P0J0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000186010","url":"https://platform.opentargets.org/target/ENSG00000186010/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:17194","ensembl":"ENSG00000186010","uniprot":"Q9P0J0","entrez":"51079","biology":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. Location: Mitochondrion inner membrane; Nucleus (UniProt). Locus 19p13.11 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ndufa13/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}