{"entity":{"id":"nectin2","kind":"target","name":"CD112 (nectin-2)","aka":["CD112","PVRL2","nectin-2","PRR2","HVEB"],"tldr":"CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.","summary":"NECTIN2 (chromosome 19q13.32) is a modulator of T-cell signalling that acts as a costimulator or a coinhibitor depending on the receptor it binds: through CD226 it stimulates proliferation and the production of IL-2, IL-5, IL-10, IL-13 and interferon gamma, through PVRIG it inhibits proliferation, and the two interactions are competitive; it is ubiquitously expressed and a probable cell-adhesion protein (UniProt Q92692). TIGIT binds PVR (CD155) or NECTIN2 (CD112) on antigen-presenting cells and sends inhibitory signals to the T cell or NK cell (UniProt Q495A1).","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:9707","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9707"},{"label":"UniProt Q92692","url":"https://www.uniprot.org/uniprotkb/Q92692/entry"},{"label":"NCBI Gene 5819","url":"https://www.ncbi.nlm.nih.gov/gene/5819"}],"tags":["checkpoint-map"],"related":["pvrig","tigit","pvr"],"cancers":[],"sections":[],"technologies":["tigit-blockade"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-immunity-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"NECTIN2","role":["immune-checkpoint"],"sources":[{"label":"HGNC HGNC:9707","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9707","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt Q92692","url":"https://www.uniprot.org/uniprotkb/Q92692/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:9707","ensembl":"ENSG00000130202","uniprot":"Q92692","entrez":"5819","biology":"The second ligand of the TIGIT axis and the sole established ligand of PVRIG.","whereFound":["Ubiquitous (UniProt Q92692)"],"targetClass":"checkpoint","prevalence":[]},"route":"/targets/nectin2/","neighbours":{"target":[{"id":"pvr","kind":"target","name":"CD155 (PVR)","route":"/targets/pvr/"},{"id":"pvrig","kind":"target","name":"PVRIG (CD112R)","route":"/targets/pvrig/"},{"id":"tigit","kind":"target","name":"TIGIT","route":"/targets/tigit/"}],"technology":[{"id":"tigit-blockade","kind":"technology","name":"TIGIT blockade","route":"/technologies/tigit-blockade/"}],"pathway":[{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"}]}}