{"entity":{"id":"nedaplatin","kind":"drug","name":"Nedaplatin","aka":["254-S"],"tldr":"Nedaplatin is a Japanese platinum drug, approved there in 1995, used for head and neck, oesophageal, lung, cervical and other squamous cancers as a gentler alternative to cisplatin on the kidneys; it has never been approved in the West.","summary":"Shionogi developed nedaplatin to keep cisplatin's activity while reducing kidney damage and vomiting. Japan approved it in 1995 for head and neck, testicular, lung, oesophageal, ovarian and cervical cancers, and China followed. Randomised trials in Japan and China have shown it comparable to cisplatin with radiotherapy in nasopharyngeal and cervical cancer and in squamous non-small cell lung cancer with docetaxel, with less nephrotoxicity but more thrombocytopenia. It is not approved in the United States or Europe, where carboplatin fills the role of the better tolerated platinum.","status":"established","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Nedaplatin","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Nedaplatin"},{"label":"ChEMBL CHEMBL2107854","url":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107854"}],"tags":["gap-fill","chembl-universe"],"related":[],"cancers":["head-and-neck","esophageal","nsclc","cervical"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["cisplatin","carboplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"brand":"Aqupla","modality":"Second-generation platinum cytotoxic, intravenous","mechanism":"A platinum complex that forms DNA cross-links like cisplatin but with a glycolate leaving group that makes it less nephrotoxic and emetogenic.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/nedaplatin/","neighbours":{"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"}],"trial":[{"id":"nct06953323","kind":"trial","name":"A Phase I/II Study of WJB001 Combination Therapy on Safety and Efficacy for Advanced Solid Tumors","route":"/trials/nct06953323/"}]}}