{"entity":{"id":"nedd9","kind":"target","name":"NEDD9","aka":["neural precursor cell expressed, developmentally down-regulated 9","Enhancer of filamentation 1","HEF1","CAS-L","CASS2"],"tldr":"NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7733","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7733"},{"label":"UniProt Q14511","url":"https://www.uniprot.org/uniprotkb/Q14511/entry"},{"label":"NCBI Gene 4739","url":"https://www.ncbi.nlm.nih.gov/gene/4739"},{"label":"Ensembl ENSG00000111859","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111859"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NEDD9","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7733","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7733","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14511","url":"https://www.uniprot.org/uniprotkb/Q14511/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NEDD9","url":"https://civicdb.org/features/3852","note":"1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:7733","ensembl":"ENSG00000111859","uniprot":"Q14511","entrez":"4739","biology":"Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form. Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs. Plays a role in the organisation of T-cell F-actin cortical cytoskeleton and the centralisation of T-cell receptor microclusters at the immunological synapse. Location: Cytoplasm, cell cortex; Nucleus; Golgi apparatus; Cell projection, lamellipodium (UniProt). Locus 6p24.2 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/nedd9/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}