{"entity":{"id":"neil1","kind":"target","name":"NEIL1","aka":["nei like DNA glycosylase 1","Endonuclease 8-like 1","FLJ22402","hFPG1","NEI1","FPG1"],"tldr":"NEIL1 (Endonuclease 8-like 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.89, animal model 0.39, genetic association 0.08).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18448","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18448"},{"label":"UniProt Q96FI4","url":"https://www.uniprot.org/uniprotkb/Q96FI4/entry"},{"label":"NCBI Gene 79661","url":"https://www.ncbi.nlm.nih.gov/gene/79661"},{"label":"Ensembl ENSG00000140398","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140398"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NEIL1","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18448","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18448","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96FI4","url":"https://www.uniprot.org/uniprotkb/Q96FI4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140398","url":"https://platform.opentargets.org/target/ENSG00000140398/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18448","ensembl":"ENSG00000140398","uniprot":"Q96FI4","entrez":"79661","biology":"Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Chromosome (UniProt). Locus 15q24.2 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/neil1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}